Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.7
USERS' SCORE
Good
Based on 19 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis—including gastroscopy, ultrasound, and blood tests—we initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient’s condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
Most Useful Reviews
9
Lowered homocysteine
59 people found this helpful
I'd previously ordered a costlier product aimed at reducing homocysteine, which can harm blood vessels and lead to complications like miscarriages. After taking two tablets of this supplement for some time, my homocysteine levels significantly dropped from 9.3 to 5.5—an excellent result! Especially important for women planning to conceive.
Read More
9
Numbness relief
7 people found this helpful
I experienced significant neck issues leading to carpal tunnel syndrome, causing numbness. After taking B12, I noticed an improvement within a week, and much of my discomfort has vanished after a month. I highly recommend it to those facing similar symptoms.
Read More
9
Effective support
1 people found this helpful
Following my endocrinologist's advice, I used this methyl formula to enhance the absorption of B12 and B9 while planning my pregnancy. My B12 and B9 levels increased significantly after two months, confirming its efficacy for treating my autoimmune disorder.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.7
- All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Read More
9
Biotin deficiency mimics neurological disorders
We explored three cases of biotinidase deficiency (BTD) that were misdiagnosed as neuromyelitis optica spectrum disorder (NMOSD) due to similar symptoms and neuroimaging results. Initially, two patients responded to immune therapy but later relapsed, while one showed no improvement. Interestingly, after timely diagnosis and biotin supplementation, two patients exhibited remarkable recoveries in both motor function and vision. This highlights the critical need for accurate diagnosis, as early treatment of BTD can lead to significant improvements.
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9
We aimed to understand how high doses of vitamins B1, B6, and B12 might help improve vision in people suffering from relapsing-remitting multiple sclerosis (RRMS) who face persistent visual loss after acute optic neuritis. In our pilot study, we included sixteen patients who had been diagnosed with RRMS and had visual disabilities resulting from an earlier bout of optic neuritis. Each participant received a daily regimen of high-dose vitamins for 90 days, alongside their regular disease-modifying therapies.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Read More
9
We investigated the potential benefits of a treatment composed of advanced glycation end products inhibitors, which included vitamin B6, on patients with rheumatoid arthritis (RA). The study focused on how this combination therapy could enhance endothelial function in individuals suffering from this autoimmune disorder.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
Read More
9
Folate's Role in Rheumatoid Arthritis
We explored the potential of folate-modified ginger-derived extracellular vesicles (FA-GDEVs) in treating rheumatoid arthritis (RA). This innovative approach aims to tackle the ongoing inflammation and joint damage that characterizes this autoimmune disorder. By using folate, which selectively targets specific receptors on inflammatory cells, we specifically directed these vesicles to M1 macrophages in inflamed joints.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Our findings show that FA-GDEVs can help encourage a shift from harmful M1 macrophages to a healing M2 phenotype. This shift is significant because M2 macrophages play a role in tissue repair and reducing inflammation. We also investigated how these vesicles activate the PI3K-AKT pathway, a crucial cellular pathway involved in regulating immune response.
In our in vivo studies, we noted that these folate-modified vesicles successfully concentrated in affected joints and led to a marked reduction in RA symptoms. Overall, it’s clear that FA-GDEVs present a promising therapeutic option for those suffering from rheumatoid arthritis, bringing together safety, affordability, and effectiveness in one approach.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowered homocysteine
59 people found this helpful
I'd previously ordered a costlier product aimed at reducing homocysteine, which can harm blood vessels and lead to complications like miscarriages. After taking two tablets of this supplement for some time, my homocysteine levels significantly dropped from 9.3 to 5.5—an excellent result! Especially important for women planning to conceive.
Read More
9
Numbness relief
7 people found this helpful
I experienced significant neck issues leading to carpal tunnel syndrome, causing numbness. After taking B12, I noticed an improvement within a week, and much of my discomfort has vanished after a month. I highly recommend it to those facing similar symptoms.
Read More
9
Effective support
1 people found this helpful
Following my endocrinologist's advice, I used this methyl formula to enhance the absorption of B12 and B9 while planning my pregnancy. My B12 and B9 levels increased significantly after two months, confirming its efficacy for treating my autoimmune disorder.
Read More
7.5
Effective for pregnancy
201 people found this helpful
An excellent supplement prescribed by my gynaecologist as I prepared for pregnancy, addressing my significant vitamin deficiency. After a couple of months, my retests showed near-normal levels, so I continue to order this supplement. I highly recommend it.
Read More
9
Suitable for vegetarians
22 people found this helpful
I ordered this for my husband and myself after discovering we had low B12 and B9 levels. It’s suitable for vegetarians and contains high-quality active forms of B12 and folic acid. We take one lozenge daily, and I’m very satisfied with our progress.
Read More
Frequently Asked Questions
9
Numbness relief
7 people found this helpful
I experienced significant neck issues leading to carpal tunnel syndrome, causing numbness. After taking B12, I noticed an improvement within a week, and much of my discomfort has vanished after a month. I highly recommend it to those facing similar symptoms.
9
Effective support
1 people found this helpful
Following my endocrinologist's advice, I used this methyl formula to enhance the absorption of B12 and B9 while planning my pregnancy. My B12 and B9 levels increased significantly after two months, confirming its efficacy for treating my autoimmune disorder.
9
Increased hemoglobin
11 people found this helpful
I purchased this for my mother, who had low hemoglobin due to digestive issues. After three months of taking it, her haemoglobin returned to normal, and her health improved significantly. We are very pleased with the results.
9
Lowered homocysteine
59 people found this helpful
I'd previously ordered a costlier product aimed at reducing homocysteine, which can harm blood vessels and lead to complications like miscarriages. After taking two tablets of this supplement for some time, my homocysteine levels significantly dropped from 9.3 to 5.5—an excellent result! Especially important for women planning to conceive.
4
Minimal effects
Despite knowing that B12 is beneficial for treating autoimmune disorders, I didn't notice any improvement in my anxiety or energy levels, yet I plan to continue as I believe it is still worthwhile.
9
Improved iron absorption
22 people found this helpful
Since discovering my anemia, I spent significantly on treatments that yielded little improvement. After starting iron alongside B12, my results improved remarkably. B vitamins, crucial for lowering homocysteine levels, made a noticeable difference in my health.
7.5
Methylated benefits
1 people found this helpful
These B vitamins are ideal for those with autoimmune disorders. They significantly reduce homocysteine, enhancing absorption compared to regular folic acid. I’ve noticed substantial improvements in my health since integrating this methylated product into my routine.
7.5
Reduced homocysteine
I chose this complex from Jarrow to lower my homocysteine levels, as high levels can complicate autoimmune disorders, especially when planning a pregnancy. The package offers long-term supply and the taste is pleasant.
7.5
Balanced complex
2 people found this helpful
This is an excellent balanced B vitamin complex that I took to address my deficiency and help manage my autoimmune disorder, particularly lowering my homocysteine levels effectively over two months.
9
Suitable for vegetarians
22 people found this helpful
I ordered this for my husband and myself after discovering we had low B12 and B9 levels. It’s suitable for vegetarians and contains high-quality active forms of B12 and folic acid. We take one lozenge daily, and I’m very satisfied with our progress.
8
We investigated the dietary and lifestyle factors associated with autoimmune gastritis (AIG) among Chinese patients. Our study involved 479 individuals across seven centers in China, where we collected detailed clinical and lifestyle data.
From the findings, we noticed that most AIG patients were middle-aged females. Interestingly, our analysis highlighted that a diet rich in vitamin B12 appeared to play a protective role against AIG. This means that the more vitamin B12 included in the diet, the better the potential outcomes regarding autoimmune gastritis.
Furthermore, we established a predictive model that relied on various factors. Alongside vitamin B12, using larger amounts of cooking oil and having comorbid autoimmune thyroid disease emerged as key risk factors for developing AIG. The predictive model demonstrated promise, with ROC curve scores indicating a reasonable ability to differentiate AIG patients from others.
Overall, our exploration suggests that dietary habits, including vitamin B12 intake, can be pivotal in managing the risk and prognosis of autoimmune gastritis. However, we recognize that additional research is essential to fully understand the effects of vitamin B12 in this context.
From the findings, we noticed that most AIG patients were middle-aged females. Interestingly, our analysis highlighted that a diet rich in vitamin B12 appeared to play a protective role against AIG. This means that the more vitamin B12 included in the diet, the better the potential outcomes regarding autoimmune gastritis.
Furthermore, we established a predictive model that relied on various factors. Alongside vitamin B12, using larger amounts of cooking oil and having comorbid autoimmune thyroid disease emerged as key risk factors for developing AIG. The predictive model demonstrated promise, with ROC curve scores indicating a reasonable ability to differentiate AIG patients from others.
Overall, our exploration suggests that dietary habits, including vitamin B12 intake, can be pivotal in managing the risk and prognosis of autoimmune gastritis. However, we recognize that additional research is essential to fully understand the effects of vitamin B12 in this context.
8
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
8
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
8
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
References
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- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Cao AP, Wang YY, Shen YY, Liu YH, Liu JY, et al. Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling. Nutrients. 2024;16. 10.3390/nu16162665
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. 10.1136/bcr-2023-258703
- Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. 10.1111/jcmm.15917
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. 10.5582/ddt.2020.03031
- Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. 10.1016/j.msard.2020.102132
- Sande JS, Ulvik A, Midttun Ø, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. J Nutr. 2019;149:770. 10.1093/jn/nxz001
- Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. 10.1111/j.1756-185X.2011.01679.x
- Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. 10.1186/s12951-025-03096-5
- Nasra S, Bhatia D, Kumar A. Targeted Macrophage Re-Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate-Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthc Mater. 2024;13:e2400679. 10.1002/adhm.202400679
- Pesqueda-Cendejas K, Parra-Rojas I, Campos-López B, Mora-García PE, Ruiz-Ballesteros AI, et al. Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. 2024;33:918. 10.1177/09612033241257158
- Avalos-Salgado FA, Gonzalez-Lopez L, Gonzalez-Vazquez S, Ponce-Guarneros JM, Santiago-Garcia AP, et al. Risk Factors Associated with Adverse Events Leading to Methotrexate Withdrawal in Elderly Rheumatoid Arthritis Patients: A Retrospective Cohort Study. J Clin Med. 2024;13. 10.3390/jcm13071863
- Patel AV, Morgan SL, Green R, Danila MI, Merriman TR, et al. Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid. Am J Med Sci. 2024;368:33. 10.1016/j.amjms.2024.03.020
- Wells L, O'Hara N, Frye RE, Hullavard N, Smith E. Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population. J Pers Med. 2024;14. 10.3390/jpm14020166
- Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. 10.1111/jgh.16912
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- Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. 10.1186/s13256-024-05002-3
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
- Xiang H, Cai M. Coexistence of Guillain-Barré Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. 10.7759/cureus.63084
- Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. 10.1126/scitranslmed.adl3758
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. 10.7759/cureus.58601
- Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. 10.1111/pai.14135
- Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. 10.1007/s13365-024-01203-0
- Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. 10.1016/j.bbrc.2024.149668
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. 10.1007/s00296-024-05539-y
